研究成果： |
立足重大传染病预防需求，依据病原微生物致病和预防机制，结合分子佐剂理化性质特征，聚焦于疫苗佐剂的设计、评价和机制研究，已建立铝盐、纳米乳和脂质体多模式佐剂/抗原递送平台，部分佐剂技术已转化应用于3项疫苗临床研究和多项疫苗临床前研究。主持国家十二五科技重大专项子课题、国家重点研发计划子课题、吉林省科技计划重点研发项目和企业技术合作开发项目等科研项目累计11项；在Acta Pharmaceutica Sinica B、J Control Release、NPJ Vaccines等杂志发表SCI论文40余篇，其中第一作者/通讯作者26篇，被引用1700余次，H指数24，受邀参编中英文专著共4部。 现为中国疫苗行业协会核酸疫苗分会委员、中国疫苗行业协会细菌感染与疫苗研究专委会委员，受国家新药审评中心（CDE）邀请参与包括核酸疫苗和新型佐剂疫苗在内的10余个疫苗品种的临床和上市审评,受CDE邀请以技术专家身份参与制定我国《疫苗佐剂非临床研究技术指导原则》和《疫苗佐剂药学研究技术指导原则》。 Selected Publications: 1. Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution. Xin Xu, Lili Cui, Yong Zhang*, Jingkai Gu*. Acta Pharmaceutica Sinica B (中科院1区Top，IF 14.6). //doi.org/10.1016/j.apsb.2025.11.023
2. Biodistribution and mechanisms of action of MF59 and MF59-like adjuvants.Wen Zhang, Haicheng Cui, Jixuan Xu, Mingze Shi, Lijun Bian, Lili Cui*, Chunlai Jiang, Yong Zhang*. J Control Release (中科院1区Top，IF 11.5). 2025, 378:573-587. 3. Optimizing rabies mRNA vaccine efficacy via RABV-G structural domain screening and heterologous prime-boost immunization Dongdong Li, Xuan Wang, Gaotian Li, Jingying Zhou, Lijun Bian, Xiaoyan Zhao, Liao Xing, Juanmei Zeng, Jiaxing Cui, Lili Cui, Yong Zhang*, Yan Chen*. NPJ Vaccines (中科院2区Top，IF 7.0). 2025,10(1):43.
4. Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats Cenrong Wang, Xin Tang, Chenghan Jiang, Yu Zhang, Bo Han, Yi Sun, Jianfeng Guo, Hanyu Peng, Zihan Wang, Yipeng Wang, Jialu Zhang, Yong Zhang*, Chunlai Jiang*. Front Immunol (中科院2区，IF 5.9). 2025,16:1530736
5. Heterologous prime-boost immunization strategies using varicella-zoster virus gE mRNA vaccine and adjuvanted protein subunit vaccine triggered superior cell immune response in middle-aged mice. Dongdong Li, Lijun Bian, Lili Cui, Jingying Zhou, Gaotian Li, Xiaoyan Zhao, Liao Xing, Jiaxing Cui, Bo Sun, Chunlai Jiang, Wei Kong,Yong Zhang*, Yan Chen*. Int J Nanomedicine. 2024:19:8029–8042. 6. Immune Response of Inactivated Rabies Vaccine Inoculated via Intraperitoneal, Intramuscular, Subcutaneous and Needle-Free Injection Technology-Based Intradermal Routes in Mice. Huiting Zhao, Peixuan Li, Lijun Bian, Wen Zhang, Chunlai Jiang, Yan Chen*, Wei Kong,Yong Zhang*. Int J Mol Sci. 2023,24(17):13587. 7. Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice. Lijun Bian, Yu Zheng, Xiaohong Guo, Dongdong Li, Jingying Zhou, Linyao Jing, Yan Chen, Jingcai Lu, Ke Zhang, Chunlai Jiang*,Yong Zhang*，Wei Kong. Front Immunol. 2022,13:938598. 8. Immune response of C57BL/6J mice to herpes zoster subunit vaccines formulated with nanoemulsion-based and liposome-based adjuvants. Lei He, Bo Sun, Yingnan Guo, Kunming Yan, Dawei Liu, Yang Zang, Chunlai Jiang*,Yong Zhang*, Kong W. Int Immunopharmacology. 2021,101:108216. 9. Respiratory Syncytial Virus F Subunit Vaccine With AS02 Adjuvant Elicits Balanced, Robust Humoral and Cellular Immunity in BALB/c Mice. Yu Zheng, Lijun Bian, Huiting Zhao, Yulan Liu, Jingcai Lu, Dawei Liu, Ke Zhang, Yueshuang Song, Yusi Luo, Chunlai Jiang*, Yan Chen,Yong Zhang*, Kong W. Front Immunol. 2020,11:526965. 10. The effect of size, dose, and administration route on zein nanoparticle immunogenicity in BALB/c mice. Feng Li, Yan Chen, Shubo Liu, Xue Pan, Yulan Liu, Huiting Zhao, Xiujing Yin, Chunlin Yu, Wei Kong,Yong Zhang*. Int J Nanomedicine. 2019,14:9917-9928. 11. Comparison of four adjuvants revealed for strongest protection against lethal pneumococcal challenge following immunization with PsaA-PspA fusion protein and AS02 as adjuvant. Xiaorui Chen, Bo Li, Jinfei Yu, Yue Zhang, Tiejun Gu,Yong Zhang*, Wei Kong, Yongge Wu*. Med Microbiol Immun. 2019, 208(2):215-226. 12. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Wei Shi, Yiming Kou, Jinghui Xiao, Lijuan Zhang, Feng Gao, Wei Kong, Weiheng Su, Chunlai Jiang*,Yong Zhang*. Vaccine. 2018,36(33):5020-5029.
Chapters: 1. 王宾，钟一维，张勇，孙冰冰，陈春英，刘晶。第11章 疫苗佐剂研究，《疫苗创新技术》，主编 王佑春， ISBN:9787521441309，中国医药科技出版社，2024。 2. Zhang Yong*, Cui Lili, Chen Yan and Kong Wei. Chapter 1: Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope. (Invited Chapter), in Ed, Atta-ur-Rahman, Frontiers in Clinical Drug Research- Diabetes and Obesity, Bentham Science Publishers, 2016, volume 3, page: 3-58. DOI: 10.2174/9781681082479116030003; ISBN: 978-1-68108-248-6. 3. 张勇，陈妍。第17章 脂质体在其他给药系统中的应用，《脂质体技术》，主编 邓英杰， ISBN:9787117084093/R.8410，人民卫生出版社，2007。
Invited presentations: 1. 疫苗佐剂研发现状与前沿进展。吉林省“生物大健康产业技术创新”高级研修班，2025.11，长春
2. 佐剂在重组带疱疫苗中的应用。中国疫苗行业协会"全龄健康，家庭为盾"疫苗接种策略研讨会，2025.9，长沙
3. 国内外新型冠状病毒疫苗概览。抗新冠病毒药物治疗进展学术交流会，2022.11，深圳 4. 佐剂在上市新冠疫苗中的应用及未来发展趋势。新型疫苗研发峰会，2022.11，上海 5. 人用疫苗佐剂的历史与现状。银水湾论坛，2021.01，哈尔滨 6. 新型佐剂在呼吸道病毒性疫苗中的临床应用。中国生物制品年会，2020.11，珠海 7. 上市疫苗佐剂类型及作用机理。中国疫苗创新论坛，2020.09，泰州 8. Adjuvants for Vaccine Development. AIDS and Vaccines, 2018.09, Changchun |
